哈尔滨工业大学（深圳）学术讲座

演讲人Speaker：林原 教授

题目Title: Development of microfluidic- and diamond-based methods for cell biological applications

时间Date：2024年12月18日  Time：16：00

地点Venue：H栋 303室

邀请人Host：方超 副教授

内容摘要Abstract：

Recent advances in microfabrication and material engineering have enabled us to develop novel methods for conducting accurate and multi-functional measurements at molecular and cellular levels. In this talk, an integrated microdevice developed by us for concurrent measurement of the mechanical and electrical properties of living cells will be introduced first, and its superb performance (when compared to conventional approaches) in the characterization and phenotyping of cells will be demonstrated. After that, I will present our recent efforts in the engineering and fabrication of diamond materials for different biomedical applications. Specifically, I will show how defects in nanodiamonds can be used to monitor rotational motions induced by cellular forces. In addition, methods for fabricating diamond particles with distinct shapes, including sphere, twisted surface, pyramidal islands, nano-flowers and porous polygons, as well as the underling physical mechanisms will be also presented. Finally, I will demonstrate that wafer-scale, ultrathin and transferable polycrystalline diamond membranes can be produced by simple mechanical exfoliation. Our experimental and theoretical studies reveal that the quality of the exfoliated films depends on the peeling angle and membrane thickness, where largely intact diamond membranes can be robustly produced within an optimal operation window. The ultra-flat and ultra-flexible nature of the membrane supports standard micromanufacturing techniques and allows for direct strain engineering and bio-sensing applications.

个人简介(About the speaker):

Yuan Lin earned his B.S. and M.S. in Engineering Mechanics from Tsinghua University, followed by another M.S. in Applied Mathematics and a Ph.D. in Solid Mechanics from Brown University. His research on cell/tissue mechanics, bio-microfluidics/MEMS, and functional materials led to publications in top journals, including Nature, PNAS, Nature Communications, Science Advances and PRL. Prof. Lin has served as Chair of the Gordon Research Conference on Nano-Mechanical Interfaces and keynote/invited speaker and organization committee member in more than 30 international conferences. As the PI or Co-PI, he has secured 15 research grants from Hong Kong government and NSFC. Prof. Lin currently serves as the Secretary for the Hong Kong Society of Theoretical and Applied Mechanics.