Speaker：Adam Williamson （Linköping University）

Inviters: 马婷、叶辰飞

Title:   Non-invasive Temporal Interference Stimulation in the Human Brain: Biophysical Differences between Kilohertz and Amplitude-Modulated Stimulation

Date：2025-06-09（Mon. 周一）     Time：14:30-15:20

Venue:  L204

摘要（Abstract)：

Temporal Interference (TI) stimulation has emerged as a promising new non-invasive neuromodulation method, capable of focally targeting deep brain structures – specifically by using combinations of overlapping kilohertz frequencies. However, the underlying biophysical mechanisms of TI stimulation are not yet well-understood. In this work, Prof. Adam Williamson will discuss recent findings on the distinct biophysical processes which differentiate TI from conventional kilohertz frequency stimulation. Specifically, he will show investigations combining patient-specific computational modeling, intracerebral recordings in humans with Parkinson’s disease and Epilepsy, and single-neuron simulations. The results reveal unique neuromodulatory characteristics of TI amplitude-modulated (AM) fields compared to unmodulated kilohertz fields and provide an improved mechanistic understanding, to correspondingly improve strategies of TI neuromodulation, with significant relevance to biological psychiatry and therapeutic interventions targeting deep brain networks.

报告人简介(About the speaker):

Adam Williamson is a Professor of Neurophysiology at Linköping University, Sweden, and a Research Team Leader at St. Anne’s University Hospital in Brno, Czech Republic.

He received a bachelors and masters in electrical engineering from Texas Tech University, USA, and obtained his doctorate at the Technische Universität Ilmenau, Germany. Previously, he served as research scientist at the Institute of Neuroscience (INS), a part of Inserm at Aix-Marseille University (AMU) in France. He is a recipient of 5 European Research Council (ERC) grants.

His research focuses on in vivo applications of new electronic devices and methods of brain stimulation in epilepsy. His most recent ERC Consolidator grant specifically focuses on non-invasive deep brain modulation using Temporal Interference, a new non-invasive deep brain modulation method, to control epileptic brain activity in drug-resistant epilepsy patients.