哈尔滨工业大学（深圳）学术讲座

演讲人Speaker：Prof.Chunxia Zhao

题目Title: Bioinspired Nanomaterials and Devices for Cancer Nanomedicine

时间Date：2023年 11月 6日       Time：15:00-15;30

地点Venue：T5 204  

内容摘要Abstract：

Nanotechnology holds great promise for cancer diagnosis and treatment. A wide range of nanoparticles have been developed ranging from polymer particles to lipids, proteins and other synthetic compounds for cancer drug delivery. However, only a handful cancer nanomedicines have been approved by the FDA (such as Doxil, and Abraxane). This demonstrates the huge gap between laboratory research and clinical translation of cancer nanomedicines, mainly due to several key barriers: (1) challenges in large-scale production of nanomedicine with good reproducibility and well-controlled properties; (2) incomplete understanding of the interactions between nanoparticles and biological systems; (3) targeted delivery. To address these fundamental issues, my group has been focusing on the development of platform technologies for producing nanoparticle libraries with reproducible and systematically varied properties (liposomes, polymer nanoparticles and nanocapsules) with high drug loading. We also developed different strategies for improving targeted delivery. Particularly, we developed a bioinspired nanotechnology integrating naturally derived cell membranes for enhanced biointerfacing capabilities and nanoparticles for incorporation of various payloads for targeted delivery, which provides a revolutionising strategy for fabricating nanoscale artificial cells. We have also developed biomimicking chips (Tumor-on-a-Chip, Tumor-Vasculature-on-a-Chip) to fundamentally understand nanoparticle extravasation and their tumor accumulation.

个人简介(About the speaker):

Professor Chun-Xia Zhao is a Professor and an Australian National Health and Medical Research Council (NHMRC) Leadership Fellow in the School of Chemical Engineering at University of Adelaide, the Deputy Director of an Australian Research Council (ARC) Centre of Excellence, and an Honorary Professor at the Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. She leads a research group focusing on bioinspired engineering, biomimetic nanomaterials and microfluidics for drug delivery and controlled release. She has been awarded three national prestigious fellowship (Australian Postdoctoral Fellowship 2011-2014 and ARC Future Fellowship 2015-2020, and NHMRC Leadership Fellowship 2022-2026). Her research in bio-inspired nanotechnology and microfluidics has attracted more than $50 M research funding as the chief investigator including $35M ARC Centre of Excellence, $7.35M Cooperative Research Centres Projects (CRC-P) Grant, $10M MRFF grant, and many university and industry grants. Prof. Zhao has published more than 120 referred articles in international top refereed journals such as PNAS, Science Advances, Nature Comm, Angewandte Chemie International Edition, ACS Nano, Small, and so on. She has been focusing on innovative research as evidenced by her seven patents. She has built extensive collaborations with scientists at top universities such as Harvard University, Brown University, etc. She serves as the Editors (Executive Editor of Chemical Engineering Science journal, etc.), Editorial Board member for several journals.