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Structure-mechanical behaviour relation of microtubules in cells
发布时间:2017-09-18 15:24:51 2262

 

 

内容摘要Abstract:
Microtubules (MTs) play a central role in maintaining cell shapes/rigidity, providing tracks for intra-cellular transportation and facilitating the inter-cellular mobility. The mechanics of MTs has attracted considerable attention in the last two decades. One of the major issues is the structure-mechanical behaviour relation of MTs. The present talk focuses on the two typical examples, i.e., the relation between MT helicity and transverse vibration, and inter-protofilament sliding and MT bending. In the analyses, a cost-effective molecular structure model is used, which accounts for the structural details of MTs and enjoys improved efficiency relative to molecular dynamics simulations. It is found that the helical structure leads to a 3D transverse vibration with adjacent half wavelength oscillating in different planes while the inter-protofilament sliding results in the length-dependence of bending stiffness and softening/stifferning effect on MTs depending on loading conditions. 

个人简介(About the speaker):
王成原2006年毕业于加拿大阿尔博塔大学机械系,获博士学位,并于该系及悉尼大学先进材料研究中心从事博士后研究。2007年底于英国斯旺西大学工学院任高级讲师、博士生导师。2013年加入江苏大学土木工程与力学学院任特聘教授、力学学科微/纳米力学、多尺度力学基础方向负责人,并获选2013年江苏省双创人才。王博士的研究包括(1)碳纳米管/石墨烯/氮化硼/氮化镓纳米结构的变形、断裂机理,褶皱/屈曲和振动分析;(2)细胞结构件力学行为及结构与性能关系;(3)功能纳米复合材料的制备和力电耦合性能研究。研究采用了计算机模拟,力学理论分析及实验手段相结合的多尺度表征方法。研究成果发表在Nanoscale, Physical Review B及 Nanotechnology 等刊物,迄今发表SCI论文72篇,SCI引用1380次。