I have a Master in Chemical Engineering, a PhD in Biochemical Engineering and a MBA in
pharmaceutical business. I have international research experience in the academic sector
as researcher and professor and in private sector as group leader and manager in companies
that were making bio-artificial tissues. I have worked in various fields related with biosciences
and biotechnology such as physical chemistry, molecular biology, bioprocesses for production
of pharmaceuticals such as recombinant proteins and viral vectors for gene therapy. My work is experimental and computational. The last years I combined my experience in the field of Tissue Engineering-Regenerative Medicine where I developed a new methodology to make bio-artificial tissues with properties as the real ones. I applied this methodology in a European project, in
which I was the coordinator, for the design of a bio-artificial neuronal tissues with the capacity to memorize electrical signals (Neuro-engineering). This methodology (Developmental Engineering)
is widely known now and it has been characterized as the new paradigm in the field of Tissue Engineering.
Tissue Engineering, Regenerative Medicine, Biomedical Engineering, Complex Systems, Developmental Biology.
Search for the principles or laws that nature uses to make tissues and organs and use them to make bio-artificial analogues for transplantations.
17/03/1987 Diploma (Master) in Chemical Engineering
National Technical University of Athens, Athens, GREECE.
05/10/1993 PhD in Biochemical Engineering
University of Patras, Patras, GREECE.
15/12/2006 Executive Programme in Pharma Business
EPHOS - European School of PharmaStudies, Madrid, SPAIN.
2015-present Associate Professor in Biomedical Engineering, Tissue Engineering-Regenerative Medicine. College of Sciences, Harbin Institute of Technology Shenzhen, CHINA.
2011-2015 Director (and founder) of the University of Complutense spin-off “PROMETHEUS, Bioengineering of Stem Cells and Tissues, SL”, Madrid, SPAIN.
2007-2010 Research Professor, Process Design/Development for Tissue Engineering-Regenerative Medicine. Department of Biochemistry and Molecular Biology IV, Faculty of Veterinary, University Complutense of Madrid, Madrid, SPAIN.
2005-2007 Research Professor, Process Design/Development for Tissue Engineering-Regenerative Medicine. Department of Applied Mathematics, School of Optics, University Complutense of Madrid, Madrid, SPAIN.
2003-2005 Research Professor, Process Design/Development for Tissue Engineering-Regenerative Medicine. Department of Chemical Engineering, University Rovira i Virgili, Tarragona, SPAIN.
2001-2003 R&D Manager, (Private sector), Process Design/Development for Tissue Engineering-Regenerative Medicine. Tigenix NV, (Private company Stem Cell Technology and Tissue Engineering), Leuven, BELGIUM. and Research Associate. Department of Rheumatology, Faculty of Medicine, Catholic Univ. of Leuven, Leuven, BELGIUM.
2000-2001 Chief Scientist-Group Leader, (Private sector), Process Design/Development for Tissue Engineering-Regenerative Medicine. Starlab NV. Private Research Institute for Future Technologies, Brussels, BELGIUM.
1998-1999 Governmental Research Associate, Process Design/Development in Biochemical Engineering. Biotechnology Research Institute, National Research Council of Canada, Montreal, CANADA.
1996-1997 Postdoctoral Researcher, Molecular Biology-Biochemistry. Department of Molecular Science of Medicine, Aichi Medical University, (private), Nagakute, Aichi, JAPAN.
1994-1996 Postdoctoral Researcher, Process Design/Development in Biochemical Engineering. Department of Biotechnology, Nagoya University, Nagoya, JAPAN.
1993-1994 Research Associate, Process Design/Development in Biochemical Engineering. Department of Chemical Engineering, New Jersey Institute of Technology, New Jersey, USA.
1989-1993 Research Assistant, (Ph. D. Candidate), Process Modelling/Dynamic Analysis in Biochemical Engineering.
Department of Chemical Engineering, University of Patras, Patras, GREECE.
1988-1989 Research Assistant, Molecular Biology. Biological Centre, National Hellenic Research Foundation, Athens, GREECE.
2007 -2011 Project title: In vitro neural tissue system for replacement of transgenic animals with memory/learning deficiencies. (Development of bioartificial neural tissue with memory capabilities, (emergent properties at the tissue level), from embryonic stem cells using developmental biology principles for the in vitro synaptic network development inside a biomaterial placed in a mini-fed-batch bioreactor interfaced with micro-electrode arrays for electrical stimulation and electrophysiological signal recording.)
Project number: LSHM-CT-2007-037862
European Commission contribution: 1.984.900 € (15,445,073.32 CNY), 807.000 € (6,279,507.83 CNY) for my lab.
1980 Scholarship from the State Scholarship Foundation of Greece
1980 Excellence Award from the National Technical University of Athens for ranking first in the entrance examinations
1988-1989 Fellowship from the National Hellenic Research Foundation for ranking first in the examinations in Biochemistry and Molecular/Cellular Biology
1989-1993 Fellowship for PhD from the Greek Ministry of Science and Technology
1991 Prize for poster presentation in conference "Chaotic Dynamics: Theory and Practice", NATO ASI, Patras, Greece
1994-1995 Fellowship from the Japanese-German Center Berlin for research in Japan
1995-1996 Fellowship from the European Commission for research in Japan
1997 Fellowship from the Japanese Foundation Daiko Zaidan for research in Japan
2003 Ranking second among the successful candidates in whole Spain in the field of Chemical/Biochemical Engineering during the selection from the Spanish Government of the Research Professor position, (selection based on experience and proposed research projects)
2004 Invitation by the European Science Foundation, (ESF), and the ESF‘s European Space Science Committee, (ESF-ESSC), on participation in a committee for the proposition of the future of ESA’s ELIPS and International Space Station utilisation in the field of life science, Obernai , Strasbourgh, France
A patent has been granted for a new polymer that was developed in the European project in which I was the Coordinator, and was used as a scaffolding biomaterial for the three-dimensional differentiation of stem cells to neurons, from the collaboration of my laboratory with the laboratory of Professor Janusz Rosiak of the Technical University of Lodz.
a. REREREED JOURNALS
PHYSICAL CHEMISTRY - ELECTROCHEMISTRY
1. G. Patermarakis, P. Lenas, Ch. Karavasilis and G. Papayiannis. Kinetics of Growth of Porous Anodic Al2O3 Films on Al Metal. Electrochimica Acta, 36(3-4), 709-25, 1991. (IF 4.50, Citations 94)
MOLECULAR BIOLOGY – BIOCHEMISTRY
2. V. Zoumpourlis, P.Patsilinacos, A. Kotsinas, H. R. Maurer, P. Lenas and D.Spandidos. Cisplatin Stimulates the Expression from the Human Immunodeficiency Virus Long Terminal Repeat Sequences in Human Fibroblasts. Anti-Cancer Drugs 1(1), 55-8, 1990. (IF 1.78)
3. Y. Yamada, N. Itano, M. Zako, M. Yoshida, P. Lenas, A. Niimi, M. Ueda and K. Kimata. The Gene Structure and Promoter Sequence of Mouse Hyaluronan Synthase 1 (mHAS1). Biochemical Journal 330, 1223-7, 1998. (IF 4. 779, Citations 14)
4. N. Itano, T. Sawai, M. Yoshida, P. Lenas, Y. Yamada, M. Imagawa, T. Shinomura, M. Hamaguchi, Y. Yoshida, Y. Ohnuki, S. Miyauchi, A. P. Spicer, J. A. McDonald and K. Kimata. Three Isoforms of mammalian Hyaluronan Synthase Have Distinct Enzymatic Properties. The Journal of Biological Chemistry 274(35), 25085-92, 1999. (IF 4.6, Citations 405)
BIOCHEMICAL ENGINEERING (experimental and computational)
5. P. Lenas and S. Pavlou. Periodic, Quasiperiodic and Chaotic Coexistence of Two Competing Microbial Populations in a Periodically Operated Chemostat. Mathematical Biosciences 121(1), 61-110, 1994. (IF 1.489, Citations 12, Citations 13)
6. P. Lenas, B.C. Baltzis G. Lewandowski and Y.-F. Ko. Biodegradation of Wastes in a Cyclically Operated Reactor: Theory, Experimental Verification and Optimization Studies. Chemical Engineering Science 49(24A), 4547-61, 1994. (IF 2.613, Citations 15)
7. P. Lenas and S. Pavlou. Coexistence of Three Competing Microbial Populations in a Chemostat with Periodically Varrying Dilution Rate. Mathematical Biosciences 129(2), 111-42, 1995. (IF 1.489, Citations 34)
8. J. Wang, H. Honda, P. Lenas, H. Watanabe and T. Kobayashi. Effective tPA Production by BHK Cells in Nutrients-Controlled Culture Using an On-Line HPLC Measuring System. Bioscience and Bioengineering 80(1), 107-10, 1995. (IF 1.869, Citations 12)
9. P. Lenas, T. Kitade, H. Watanabe, H. Honda and T. Kobayashi. Adaptive Fuzzy Control of Nutrients Concentration in Fed Batch Culture of Mammalian Cells. Cytotechnology 25(1-3), 9-15, 1997. (IF 1.449, Citations 7)
10. H. Honda, P. Lenas, H. Watanabe, T. Kitade and T. Kobayashi. Human Antithrombin III Variant Production from Recombinant BHK Cells in a Fed-Batch Culture with On-Line Control of Glucose and Glutamine Concentrations. Bioscience and Bioengineering 85(5), 532-5, 1998. (IF 1.869, Citations 4)
11. P. Lenas, N.A. Thomopoulos, D.V. Vayenas and S. Pavlou. Oscillations of Two Competing Microbial Populations in Configurations of Two Interconnected Chemostats. Mathematical Biosciences 148(1), 43-63, 1998. (IF 1.489, Citations 10)
TISSUE ENGINEERING-REGENERATIVE MEDICINE
12. P. Lenas, A. Moreno, L. Ikonomou, J. Mayer, H. Honda, A. Novellino, C. Pizarro, E. Nicodemou-Lena, S. Rodergas and J. Pintor. The Complementarity of the Technical Tools of Tissue Engineering and the Concepts of Artificial Organs for the Design of Functional Bioartificial Tissues. Artificial Organs 32(9), 742-7, 2008. (IF 1.87, Citations 4) (Corresponding author P. Lenas)
13. P. Lenas, M Jr. Moos and F.P. Luyten. Developmental Engineering: A New Paradigm for the Design and Manufacturing of Cell-Based Products. Part I: From Three-Dimensional Cell Growth to Biomimetics of In Vivo Development. Tissue Engineering Part B: Reviews 15(4), 381-94, 2009. (IF 4.254, Citations 53)
14. P. Lenas, M Jr. Moos and F.P. Luyten. Developmental Engineering: A New Paradigm for the Design and Manufacturing of Cell-Based Products. Part II. From Genes to Networks: Tissue Engineering from the Viewpoint of Systems Biology and Network Science. Tissue Engineering Part B: Reviews 15(4), 395-422, 2009. (IF 4.254, Citations 25)
15. A.K. Bal-Price, H.T. Hogberg, L. Buzanska, P. Lenas, E. van Vliet and T. Hartung. In vitro developmental neurotoxicity (DNT) testing: Relevant models and endpoints. NeuroToxicology 31(5), 545-54, 2010. (IF 3.054, Citations 29)
16. P. Lenas, F.P. Luyten, M. Doblare, E. Nicodemou-Lena and A.E. Lanzara. Modularity in Developmental Biology and Artificial Organs: A Missing Concept in Tissue Engineering. Artificial Organs 35(6), 656-62 2011. (IF 1.87, Citations 4) (Corresponding author P. Lenas)
17. P. Lenas and F.P. Luyten. An Emerging Paradigm in Tissue Engineering: From Chemical Engineering to Developmental Engineering for Bioartificial Tissue Formation through a Series of Unit Operations that Simulate the In Vivo Successive Developmental Stages. Industrial & Engineering Chemistry Research 50(2), 482–522, 2011. (IF 2.235, Citations 4) (Corresponding author P.Lenas)
18. P. Lenas. The foundation of tissue engineering on the principles of development. Trends in Biotechnology (IF 12). Invitated.
19. P. Lenas. Engineering development: A new paradigm of tissue engineering and its impact on regulations. Regenerative Medicine (IF 2.868) Accepted.
b. BOOK CHAPTERS
20. P. Lenas, V. Saravia, J.L. Toca-Herrera , J.L. Paternain, L. Ikonomou, J. Mayer, I. Probst, J. Crawford, J.C. Vassilicos, A. Moreno, A.E. Lanzara, M. Dravaliari, A. Kolodkin and A. Novellino. Title: Functional biomimetics in Tissue Engineering: Engineering emergent tissue functions in vitro through complexity and networks science.
Chapter 9 in the book “Biomimetics in Biophysics: Model systems, experimental techniques and computation”, pp. 155-92, 2010. Editor: JL. Toca-Herrera, Senior consultant: E. Donath (Dept. Medical Biophysics, Leipzig University). Publisher: Research Signpost, Kerala, India.
(Corresponding author P. Lenas)
21. P. Lenas, F.P. Luyten, V. Saravia, J.L. Toca-Herrera , L. Ikonomou, E. Nicodemou-Lena, S. Roderges, A. Ito, H. Honda, A. Dinnyes, J. Mayer, I. Arzimanoglou, F. Martin Gordillo and A. Maccione. Title: Process biomimetics in tissue engineering: Engineering the in vitro tissue development through systems biology and networks science.
Chapter 10 in the book “Biomimetics in Biophysics: Model systems, experimental techniques and computation”, pp. 193-225, 2010. Editor: JL. Toca-Herrera, Senior consultant: E. Donath (Dept. Medical Biophysics, Leipzig University). Publisher: Research Signpost, Kerala, India.
(Corresponding author P. Lenas)
Undergraduate 1. Department of Chemical Engineering, National Technical University of Athens, Greece.
Electrochemistry experiments (one semester in 1987)
2. Department of Chemical Engineering, University of Patras, Greece.
a. Problems in Process Design (one semester in 1990 and 1991)
b. Problems in Catalysis (one semester in 1992)
c. Problems in Chemical Process Simulation and Control (one semester in 1989, 1991 and 1992)
3. Department of Chemical Engineering, University Rovira i Virgili, Tarragona, Spain.
a. Biochemical Engineering (one semester in 2003)
b. Laboratory of Chemical/Biochemical processes design-operation (one semester in 2004)
4. Harbin Institute of Technology Shenzhen. P. R. China.
a. Introduction to Biomedical Engineering technology (curriculum development) (24 h summer course and fall course, 2017)
b. Introduction to the concepts and applications of complex netwrorks (curriculum development) (16 h summer course and fall course, 2017)
c. Complex systems in Biomedical Engineering (curriculum development) (32 h fall course, 2017)
Graduate, Ph. D. course Department of Chemical Engineering, University Rovira i Virgili, Tarragona, Spain.
Tissue Engineering, (curriculum development) (one semester in 2004)
Master theses co-supervisor 1. Department of Chemical Engineering, University Rovira i Virgili, Tarragona, Spain.
Title: Biocompatible Interfaces for Tissue Engineering (2003-2005)
2. Department of Biotechnology, Nagoya University, Nagoya, Japan.
Title: Fuzzy Control of Bioreactors (1995-1996)
Other I have also supervised scientists and technicians in the private sector as Group Leader (Starlab NV, Belgium) and R&D Manager (Tigenix NV, Belgium) as well as in the team of my laboratory during the European project which included scientists with PhD. I was also supervising the activities of the consortium of the European partners and in charge of assuring that the research activities in the laboratories of the European partners are compatible between the diverse fields and according to the contract signed with the European Commission.